Chronic stress impairs autoinhibition in neurons of the locus coeruleus to increase asparagine endopeptidase activity
Hiroki Toyoda, Doyun Kim, Byeong Geon Koh, Tomomi Sano, Takashi Kanematsu, Seog Bae Oh, Youngnam Kang
This study shows chronic stress reduces 2A-AR and GIRK currents in locus coeruleus neurons, leading to increased NA-autocrine and AEP activity.
bioRxiv · Mar 10, 2025Neuroscience