Leveraging a natural murine meiotic drive to suppress invasive populations
Luke Gierus, Ayşegül C. Birand, Mark D. Bunting, G.I. Godahewa, Sandra Piltz, Kevin P. Oh, Antoinette J. Piaggio, David W. Threadgill, John Godwin, Owain Rhys Edwards, Phillip Cassey, Joshua V. Ross, Thomas A. A. Prowse, Paul Quinton Thomas
This paper proposes a gene drive strategy called tCRISPR to suppress invasive mouse populations by leveraging the t haplotype's biased transmission and inactivating mutations in a female fertility gene.
Proceedings of the National Academy of Sciences · Nov 8, 2022Peer-reviewedGenetics