David W. Threadgill

The paper examines strain and sex effects on blood levels of lead, chromium, and cadmium in Collaborative Cross mice after acute exposure, finding strain-dependent trends for lead but different patterns for chromium and cadmium.

The paper develops cardiac reference ranges for Mus musculus using the Collaborative Cross, identifies strains with disease-like phenotypes, and highlights variability sources in cardiac function measurements.

The paper identifies a genetic region on chromosome 7 associated with MRSA tolerance in mice by analyzing F1 and F2 populations from CC061 and CC024 crosses.

This study shows that reducing folate intake in aged mice decreases biosynthetic processes but does not compromise healthspan, suggesting age-dependent benefits of folate restriction.

The paper identifies a mouse tumor susceptibility gene signature (mTSGS) that predicts chemotherapy response in ERBB2-driven breast cancer, validated in both mouse models and human datasets.

The paper uses mouse models to study diet-induced metabolic syndrome, identifies strain-specific transcriptional and epigenomic changes, and tests genotype-targeted pharmacological interventions.

This study investigates the role of EGFR in mouse forebrain development through bulk and mosaic deletions, revealing region-specific effects on glial lineage formation.

This paper proposes a gene drive strategy called tCRISPR to suppress invasive mouse populations by leveraging the t haplotype's biased transmission and inactivating mutations in a female fertility gene.

The paper investigates tolerance to Salmonella Typhimurium in genetically diverse mice, identifying fibrinogen genes as key candidates distinguishing tolerance from resistance.

This study examines population structure and inbreeding in wild house mice across five continents using SNP microarray data, revealing geographic patterns and high variability in inbreeding rates.

This study investigates the genetic basis of survival differences in Salmonella Typhimurium infections across genetically diverse Collaborative Cross mouse strains, identifying new genomic regions associated with susceptibility and survival.

The paper introduces MiniMUGA, a genotyping array for mouse genetic QC, showing it effectively discriminates strains, detects genetic constructs, and identifies sex chromosome abnormalities.

The paper genetically analyzes invasive house mouse populations on two islands to understand their ancestry, inbreeding, and resistance alleles for eradication efforts.

The paper uses a diallel analysis in mice to study how host genetics affect response to influenza A virus, identifying Mx1-dependent and independent heritable effects on weight loss.