How endosomal PIKfyve inhibition prevents viral membrane fusion and entry
Nicholas Chow, Gustavo Scanavachi, Anand Saminathan, Tomas L. Kirchhausen
This paper shows that inhibiting PIKfyve causes endosomal swelling, blocking viral entry by preventing fusion and genome release, while sparing VSV-G viruses.
Proceedings of the National Academy of Sciences · May 8, 2026Peer-reviewedCell Biology