Gustavo Scanavachi

Naked antisense oligonucleotides access the cytosol during early endocytic trafficking

This study tracks antisense oligonucleotides (ASOs) through endocytic trafficking, finding that productive escape occurs early in endosomes before sequestration in late compartments.

How endosomal PIKfyve inhibition prevents viral membrane fusion and entry

This paper shows that inhibiting PIKfyve causes endosomal swelling, blocking viral entry by preventing fusion and genome release, while sparing VSV-G viruses.

SpatialDINO: A Self-Supervised 3D Vision Transformer that enables Segmentation and Tracking in Crowded Cellular Environments

SpatialDINO enables automated segmentation and tracking of crowded cellular objects using self-supervised 3D vision transformers without manual annotations or retraining.

Tau seeding in neurons enabled by transient endolysosomal perforations are confined within endolysosomes

This study shows that tau seeding in neurons occurs via transient endolysosomal perforations that remain confined within endolysosomes and require PIKfyve activity.

A Spatiotemporal Notch Interaction Map from Membrane to Nucleus

This study maps the spatiotemporal dynamics of Notch2 signaling from membrane to nucleus after ligand activation, identifying key molecular events in signal transmission.