The use of Mendelian randomization to explore the causal consequences of childhood maltreatment: consideration of assumptions and challenges
Ka Kei Sum, Amanda Hughes, Alexandra Havdahl, George Davey Smith, Laura D Howe
This paper examines the feasibility of using Mendelian randomization to study the causal effects of childhood maltreatment on mental health, highlighting challenges in interpreting MR assumptions and results.
medRxiv · Oct 17, 2025 · PreprintGenetic & Genomic Medicine