Laura D Howe

This paper examines the feasibility of using Mendelian randomization to study the causal effects of childhood maltreatment on mental health, highlighting challenges in interpreting MR assumptions and results.

This study investigates causal links between genetic liability to ADHD, ASD, and Alzheimer's disease using Mendelian randomization, finding limited evidence of association.

This study uses Mendelian randomization to identify causal risk factors for Alzheimer's disease, finding that education, fluid intelligence, and physical activity are likely causal, while most associations are consequences of early disease.

This study uses Mendelian randomization to investigate causal relationships between cytokine concentrations and Alzheimer's disease risk, finding weak evidence of a causal effect for some cytokines.

This study examines how educational attainment modifies polygenic scores for cardiovascular risk factors using UK Biobank data, finding mixed effects across traits.

This study uses Mendelian randomization to examine bidirectional causal effects between brain morphology and Alzheimer's disease risk across different life stages.

This paper uses Mendelian randomization to investigate causal links between genetic liability to ADHD/ASD and educational attainment, finding distinct causal effects for ADHD and ASD.

Multivariable and two-step Mendelian randomisation recovered direct and indirect effects with little bias in simulations with confounding or measurement error, conditions that biased phenotypic regression mediation.

The paper identifies 40 novel genetic loci associated with longitudinal pediatric bone accrual and identifies candidate effector genes through variant-to-gene mapping and functional validation.

This paper introduces within-family Mendelian randomization methods to reduce biases from family structure and shows they yield different results compared to population-based analyses.

This study uses Mendelian randomization to show education and intelligence both causally lower Alzheimer's disease risk, with intelligence having an independent effect.

This study examines how gestational age acceleration (GAA) relates to weight and height trajectories from birth to 10 years, finding initial increases in birth weight and height that reverse later in childhood.