Amanda Hughes

The paper describes the MoBaPsychGen pipeline for quality controlling and imputing genotyping data from the MoBa cohort, identifying extensive family relationships across 207,569 individuals.

This paper examines the feasibility of using Mendelian randomization to study the causal effects of childhood maltreatment on mental health, highlighting challenges in interpreting MR assumptions and results.

This paper introduces within-family Mendelian randomization methods to reduce biases from family structure and shows they yield different results compared to population-based analyses.

The paper identifies mQTLs and pleiotropic associations between DNAm, gene expression, and complex traits using SMR and a large UK cohort.

The paper examines the properties of the Horvath epigenetic clock in older individuals and finds age acceleration measures are age-dependent and may lead to misleading associations with diseases like Alzheimer's.