Author

Francesco Sirci

Institute for Research in BiomedicineORCID 0000-0002-9957-0358Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

Diego CarrellaiD· 2 shared Diego di BernardoiD· 2 shared Diego Luis MedinaiD· 2 shared Francesco NapolitanoiD· 2 shared Sandra Pisonero‐Vaquero· 2 shared Barbara MandrianiiD· 1 shared Nicola Brunetti‐PierriiD· 1 shared

Activity by Year

2017-2017 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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2 shared papersBioinformatics

Diego CarrellaORCID

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2 papers

Recent·Most cited

gene2drug: a Computational Tool for Pathway-based Rational Drug Repositioning

Francesco Napolitano, Diego Carrella, Barbara Mandriani, Sandra Pisonero‐Vaquero, Francesco Sirci, Diego Luis Medina, Nicola Brunetti‐Pierri, Diego di Bernardo

gene2drug prioritizes drugs based on their impact on transcriptional pathways of target genes, validated both computationally and experimentally for two drug repositioning cases.

Bioinformatics · Dec 10, 2017Peer-reviewedBioinformatics

Integrated Structure-Transcription analysis of small molecules reveals widespread noise in drug-induced transcriptional responses and a transcriptional signature for drug-induced phospholipidosis

Francesco Sirci, Francesco Napolitano, Sandra Pisonero‐Vaquero, Diego Carrella, Diego Luis Medina, Diego di Bernardo

The paper integrates drug chemical structures with transcriptional responses to identify noisy responses and a transcriptional signature for phospholipidosis.

npj Systems Biology and Applications · Aug 21, 2017Peer-reviewedBioinformatics