Author

Kylie J. Schache

Washington University in St. LouisORCID 0000-0002-9984-0717Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Street· 1 shared Abhirami Kannan IyeriD· 1 shared Celeste M M. KarchiD· 1 shared David J.E. KastiD· 1 shared Emma Starr· 1 shared Jacob A. MarshiD· 1 shared Rui ZhangiD· 1 shared Sally TempleiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperNeuroscience

A. Street

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1 paper

Recent·Most cited

MAPT regulates autophagic-lysosomal function and phagocytosis in human microglia

Kylie J. Schache, Rui Zhang, A. Street, Emma Starr, Jacob A. Marsh, David J.E. Kast, Sally Temple, Abhirami Kannan Iyer, Celeste M M. Karch

This study shows that pathogenic MAPT mutations impair microglial lysosomal and autophagic functions, affecting tau clearance and degradative capacity.

bioRxiv · Sep 1, 2026 · PreprintNeuroscience