David J.E. Kast

This study shows that pathogenic MAPT mutations impair microglial lysosomal and autophagic functions, affecting tau clearance and degradative capacity.

This study shows that Stathmin 1 regulates mitophagy and mitochondrial health in hematopoietic stem cells by maintaining microtubule architecture and autophagy processes.

This study identifies DFCP1 as a regulator of ATGL-mediated lipid droplet lipolysis by directly modulating ATGL activity and stabilizing its association with lipid droplets.