Modification-aware AI enables terminal chemical modifications for peptide design and discovers potent antimicrobials
Jin Xu, Marcelo D. T. Torres, Chen Li, Jian Li, Fuyi Li, Jiangning Song, César de la Fuente‐Núñez
This study introduces Termini, an AI framework for designing antimicrobial peptides with terminal modifications, achieving high hit rates and therapeutic potential in vitro and in vivo.
bioRxiv · Apr 10, 2026 · PreprintMicrobiology