Jian Li

This study identifies key residues in hPepT2 involved in polymyxin interaction, showing that modifying these residues reduces nephrotoxicity while maintaining antibacterial activity.

This study introduces Termini, an AI framework for designing antimicrobial peptides with terminal modifications, achieving high hit rates and therapeutic potential in vitro and in vivo.

This study investigates the metabolic changes in a spoT-disrupted Acinetobacter baumannii mutant under polymyxin treatment, revealing altered metabolite profiles linked to increased antibiotic susceptibility.

This study uses single-cell RNA-seq to reveal concentration-dependent survival trajectories of Acinetobacter baumannii under antibiotic treatment, uncovering hidden heterogeneity and resistance mechanisms.

This paper develops VIPA mRNA therapy, which uses viral protease-initiated pyroptosis to suppress viral replication and elicit immune responses in animal models.

This study investigates the long-term effects of Klebsiella pneumoniae infection following traumatic brain injury in mice, finding no significant impact on neurobehavioral outcomes or seizure development.

This study shows that LPS treatment after TBI causes acute neuroinflammation and gut microbiome changes but does not affect long-term outcomes.

PRISMOID is a 3D structure database for post-translational modifications and mutations, providing structural and functional insights into PTM sites and their interactions.