Laura M. Yerges-Armstrong

This study shows that plasma protein quantitative trait loci (pQTL) support therapeutic hypotheses more effectively than other genetic evidence, increasing the likelihood of drug development success.

This paper presents a blood regulatory variation map from Southern African populations, showing increased utility for interpreting African genetic studies.

This study presents the first whole genome sequence data and genome-wide association study in a Malagasy cohort, uncovering novel body composition associations and highlighting the importance of diverse populations in genomic research.

This study investigates the pleiotropic effects of SERPINA1 Z allele heterozygosity on various phenotypes using UK Biobank data, finding associations with height, gall bladder disease, heart disease, and lung function.

The paper introduces PICCOLO, a method to identify colocalized genes between GWAS and xQTLs, finding 30% of associations have at least one colocalized gene-xQTL.

Exomes of 49,960 UK Biobank participants reveal 231,631 predicted loss-of-function variants (>10-fold more than imputed data); burden tests implicate PIEZO1, MEPE, and COL6A1 in disease traits.

The paper identifies 279 new genetic signals for lung function across multiple ancestries, showing associations with COPD and pleiotropic effects.

This study identifies 64 new genetic signals for osteoarthritis using UK Biobank data, including 52 novel loci, and highlights potential therapeutic targets with existing drugs.