Michèle Ramsay

Participant engagement and feedback in microbiome projects: a case of AWI-Gen 2

This paper describes a study on participant engagement and feedback in microbiome projects in Africa, finding that culturally appropriate and timely feedback can improve trust and motivate health behaviors.

Mapping Epigenetic Gene Variant Dynamics: Comparative Analysis of Frequency, Functional Impact and Trait Associations in African and European Populations

The paper analyzes epigenetic gene variants in African and European populations to find frequency differences, trait associations, and functional impacts.

Locus 9p21.3 CAD Risk Across Diverse Populations: LD and Allelic Heterogeneity Explain Variation Across Ancestries and Reduced Replication in Africans

The paper investigates why the 9p21.3 CAD risk locus fails to replicate in African ancestry cohorts, finding ancestry-specific LD and haplotype diversity explain the lack of association.

Multi-ancestry fine-mapping accounting for ancestral and environmental heterogeneity improves resolution and interpretation

The paper introduces two fine-mapping methods to account for ancestral and environmental heterogeneity in GWAS, improving resolution of causal variants across diverse populations.

Geography, Ancestry, Age and Sex Shape Somatic Autosomal Mosaic Chromosomal Alterations in Blood

The paper examines how geography, ancestry, age, and sex influence the prevalence of somatic autosomal mosaic chromosomal alterations in blood across diverse populations.

OSBPL11 is an African-specific locus associated with 25-hydroxyvitamin D concentrations and cardiometabolic health

The paper identifies a novel genetic locus OSBPL11 associated with vitamin D levels and cardiometabolic health in African populations through genome-wide analysis.

Accounting for heterogeneity due to environmental sources in meta-analysis of genome-wide association studies

This paper introduces env-MR-MEGA, a meta-regression model that adjusts for environmental and ancestral heterogeneity in GWAS meta-analysis, improving association power.

A Southern African Map of Blood Regulatory Variation Enables GWAS Interpretation

This paper presents a blood regulatory variation map from Southern African populations, showing increased utility for interpreting African genetic studies.

Genetic Association and Transferability for Urinary Albumin-Creatinine Ratio as a Marker of Kidney Disease in four Sub-Saharan African Populations and non-continental Individuals of African Ancestry

This study conducts a GWAS on urinary albumin-to-creatinine ratio in Sub-Saharan African and non-resident African-ancestry populations, identifying two genome-wide significant loci and highlighting limited transferability of polygenic scores across populations.

Expanding the human gut microbiome atlas of Africa

This study expands the human gut microbiome atlas of Africa by analyzing 1,803 women from four countries, revealing geographic and lifestyle-associated taxa and novel microbial genomes.

Genetic insights into smoking behaviours in 10,558 men of African ancestry from continental Africa and the UK

This study identifies genetic variants associated with smoking initiation and cessation in men of African ancestry, highlighting underrepresented populations in genetic research.

G6PD variant distribution in sub-Saharan Africa and potential risks ofusing chloroquine/hydroxychloroquine based treatments forCOVID-19

The paper analyzes G6PD variant distribution in sub-Saharan Africa and highlights potential risks of using chloroquine/hydroxychloroquine for COVID-19 due to G6PD deficiency.

Genetic-substructure and complex demographic history of South African Bantu speakers

This study investigates genetic substructure and demographic history of South African Bantu speakers using genome-wide data, revealing fine-scale population structure aligned with geography and linguistics.

Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass- and fat mass-indexes

The paper identifies a West African-associated regulatory variant with a strong female-specific effect on BMI and fat mass in Brazilian admixed populations.

The extent and impact of variation in ADME genes in sub-Saharan African populations

This study characterizes ADME gene variation in sub-Saharan African populations, identifying novel variants and highlighting the need for tailored pharmacogenomic approaches.

A large cross-ancestry meta-analysis of genome-wide association studies identifies 69 novel risk loci for primary open-angle glaucoma and includes a genetic link with Alzheimer's disease

Runs of Homozygosity in sub-Saharan African populations provide insights into a complex demographic and health history

This study analyzes runs of homozygosity in sub-Saharan African populations to uncover demographic history and health-related genetic variation.

Assessing Runs of Homozygosity: A comparison of SNP Array and Whole Genome Sequence low coverage data

The paper compares Runs of Homozygosity (ROH) detected from SNP array and low coverage whole genome sequence data to establish guidelines for combining datasets.