Thomas McGregor

This study identifies genetic differences between fear-based anxiety disorders and generalised anxiety disorder using GWAS, finding partial genetic distinction and shared liability to internalising psychopathology.

The paper examines the heritability of reinforcement learning parameters related to anxiety, finding extinction learning rates correlate with anxiety severity but show no heritability, while safety learning rates have modest heritability but no genetic overlap with anxiety.

The paper uses computational modeling to show that higher anxiety severity is linked to slower safety learning and threat extinction in fear conditioning tasks.

This study uses twin data to show that fear acquisition and extinction have genetic and environmental influences, with moderate genetic overlap.