Kirstin Lee Purves

The paper examines the heritability of reinforcement learning parameters related to anxiety, finding extinction learning rates correlate with anxiety severity but show no heritability, while safety learning rates have modest heritability but no genetic overlap with anxiety.

This paper identifies 58 genome-wide significant loci for major anxiety disorders using a large meta-analysis and highlights GABAergic signaling as a potential mechanism.

The paper uses computational modeling to show that higher anxiety severity is linked to slower safety learning and threat extinction in fear conditioning tasks.

This study investigates how genetic and early environmental factors influence retrospective self-reports of childhood trauma and their association with psychopathology risk.

This study uses twin data to show that fear acquisition and extinction have genetic and environmental influences, with moderate genetic overlap.

The paper examines phenotypic and genetic relationships between cannabis use, depression, and self-harm using UK Biobank and consortium data, finding associations and genetic correlations.

This study uses family-based genetic effects to estimate heritability of neuroticism and education in the UK Biobank, finding increased heritability and couple environmental influence on education.

This study identifies five novel genome-wide significant loci for anxiety disorders and finds significant genetic correlations with depression, insomnia, and coronary artery disease.

This study investigates whether genetic variation in the Major Histocompatibility Complex (MHC) is associated with depression risk, finding no significant associations at a conservative threshold.

This study investigates the genetic and environmental links between major depressive disorder and traumatic experiences using UK Biobank data, finding shared genetic factors and distinct patterns in trauma-exposed individuals.