Thalia Catherine Eley

The paper identifies biologically distinct subtypes of MDD based on energy-related symptoms and finds genetic and metabolic differences between them.

This study identifies genetic differences between fear-based anxiety disorders and generalised anxiety disorder using GWAS, finding partial genetic distinction and shared liability to internalising psychopathology.

The paper examines the heritability of reinforcement learning parameters related to anxiety, finding extinction learning rates correlate with anxiety severity but show no heritability, while safety learning rates have modest heritability but no genetic overlap with anxiety.

The paper uses computational modeling to show that higher anxiety severity is linked to slower safety learning and threat extinction in fear conditioning tasks.

This study identifies 52 genetic variants associated with adolescent-onset depression through a large GWAS, revealing age-specific mechanisms and potential drug targets.

This study conducts a genome-wide association analysis of generalised anxiety symptom severity, identifying 80 significant variants and showing genetic correlations with other mental and physical health traits.

This study identifies genetic risk factors for panic attacks and disorder through genome-wide meta-analysis and links them to multiple body systems and neuronal functions.

This study investigates the genetic relationship between depression symptoms and Alzheimer's disease using GWAS and finds significant genetic correlations but no causal link, suggesting proxy cases may drive the overlap.

This study investigates how genetic and early environmental factors influence retrospective self-reports of childhood trauma and their association with psychopathology risk.

This study investigates genetic and environmental influences on 57 psychological traits in emerging adulthood using UK twins, finding significant genetic contributions and their associations with health and educational outcomes.

The paper introduces a gamified cognitive ability measure, Pathfinder, which shows heritability and genetic prediction of general cognitive ability.

This paper improves the prediction of behaviour problems using multi-GPS, cross-age and cross-rater composites, increasing predictive variance from less than 2% to up to 6%.

This study uses twin data to show that fear acquisition and extinction have genetic and environmental influences, with moderate genetic overlap.

This study uses genomic analysis of parent-offspring trios to estimate the genetic nurture effect on child anxiety and depression symptoms at age 8, finding significant influence on depression but not anxiety.

This study identifies traits associated with polygenic risk for depression using UK Biobank data and finds causal links between depression risk and brain structure, as well as environmental interactions.

The paper compares polygenic scores for education between adopted and non-adopted individuals in the UK Biobank to assess gene-environment interplay, finding stronger genetic prediction in non-adopted individuals.

This study uses family-based genetic effects to estimate heritability of neuroticism and education in the UK Biobank, finding increased heritability and couple environmental influence on education.

This study identifies five novel genome-wide significant loci for anxiety disorders and finds significant genetic correlations with depression, insomnia, and coronary artery disease.

This study identifies 73 genome-wide significant loci for mood disorders, revealing shared and distinct genetic factors between major depressive disorder and bipolar disorder.

The paper investigates a general dimension of psychopathology (p factor) across childhood and adolescence, finding it highly heritable and genetically stable.

This study investigates whether genetic variation in the Major Histocompatibility Complex (MHC) is associated with depression risk, finding no significant associations at a conservative threshold.

The paper examines how genetic and environmental factors influence DNA methylation at variably methylated regions in neonatal blood, finding that combined effects best explain methylation variability.

This study investigates the genetic and environmental links between major depressive disorder and traumatic experiences using UK Biobank data, finding shared genetic factors and distinct patterns in trauma-exposed individuals.

The paper applies polygenic risk scoring to a large family with bipolar and depressive disorders to study genetic risk patterns and anticipation.

Genome-wide association meta-analysis of 130,664 major depression cases and 330,470 controls identifies 44 independent risk loci enriched in cortical neurons, conserved mammalian regions, splicing networks, and antidepressant targets.