Author

Guanhua Zhu

Agency for Science, Technology and ResearchORCID 0000-0003-0030-1666Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Anders J. SkanderupiD· 2 shared Anna GaniD· 2 shared Denis OdinokoviD· 2 shared Hanaé CarriéiD· 2 shared Iain Beehuat TaniD· 2 shared Patrick B. O. TaniD· 2 shared Polly S. Y. PooniD· 2 shared Pui‐Mun WongiD· 2 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Anders J. SkanderupORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintApr 17, 2025

A Computational Framework for Analysis of cfDNA Fragmentation Profiles

Zhong Wee Poh, Guanhua Zhu, Pui‐Mun Wong…·Iain Beehuat Tan

This study introduces NDRDiff, a computational framework for analyzing cfDNA fragmentation profiles to infer gene expression and identify differentially expressed genes in cancer.

DOI 10.1101/2025.04.17.649313

humanbulk RNA-seq

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BioinformaticsbioRxivPreprintJul 28, 2023

Fragle: Universal ctDNA quantification using deep learning of fragmentomic profiles

Guanhua Zhu, Chowdhury Rafeed Rahman, Victor Getty…·Anders J. Skanderup

Fragle quantifies ctDNA from fragment length profiles using deep learning, showing high accuracy and improved detection limits across multiple datasets and sequencing types.

4 citations

humanwhole-genome sequencing

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