Zhong Wee Poh

GCfix corrects GC bias in cell-free DNA data across diverse coverages, outperforming existing methods with two new performance metrics.

This study introduces NDRDiff, a computational framework for analyzing cfDNA fragmentation profiles to infer gene expression and identify differentially expressed genes in cancer.

Fragle quantifies ctDNA from fragment length profiles using deep learning, showing high accuracy and improved detection limits across multiple datasets and sequencing types.