Thomas K. Villiger

This paper introduces a continuous biomanufacturing platform for rAAV that improves yield and reduces process complexity compared to conventional batch methods.

This paper introduces a continuous twin-column capture process (CaptureSMB) for purifying rAAV5 directly from perfusion harvest, improving yield and efficiency while maintaining product quality.

This study introduces glycosylation flux analysis to predict intracellular glycosylation fluxes in CHO cells, showing that galactosylation fluxes decrease over time and Mn addition increases them initially.