The paper analyzes gut microbiota changes across 264 cancer patients treated with 22 anticancer drugs, finding drug-specific and treatment-related microbiota alterations.

DOI 10.64898/2026.05.08.723707

humanmetagenomics

𝕏 PostBluesky

Cancer BiologybioRxivPreprintMay 5, 2026

Single-cell spatial multiomics identifies POSTN+ CAFs mediating chemoradiotherapy resistance in rectal cancer

Shunsuke A. Sakai, Masayuki Okumura, Y Morinaga…·Shun‐Ichiro Kageyama

The paper identifies POSTN-expressing cancer-associated fibroblasts (CAFs) linked to chemoradiotherapy resistance in rectal cancer using spatial multi-omics data.

1 citation

humanspatial transcriptomics

𝕏 PostBluesky

BioinformaticsbioRxivPreprintFeb 28, 2026

SpatialCompassV (SCOMV): De novo cell and gene spatial pattern classification and spatially differential gene identification

Ryosuke Nomura, Shunsuke A. Sakai, Shun‐Ichiro Kageyama…·Riu Yamashita

SCOMV classifies cell and gene spatial patterns and identifies spatially differential genes in spatial transcriptomic data without prior knowledge.

DOI 10.64898/2026.02.26.707418

humanspatial transcriptomics

𝕏 PostBluesky

BioinformaticsbioRxivPreprintJun 18, 2024

Spatial domain analysis to estimate spatiotemporal pathological mechanisms in microenvironment with single-cell spatial omics data

Shunsuke A. Sakai, Ryosuke Nomura, Satoi Nagasawa…·Riu Yamashita

The paper introduces SpatialKNife, a toolkit for analyzing single-cell spatial omics data to estimate spatiotemporal pathological mechanisms in microenvironments.

DOI 10.1101/2024.06.18.599475

humanspatial transcriptomics

𝕏 PostBluesky