Single-cell spatial multiomics identifies POSTN+ CAFs mediating chemoradiotherapy resistance in rectal cancer
Shunsuke A. Sakai, Masayuki Okumura, Y Morinaga, Ken Kato, Motohiro Kojima, Falko Hofmann, Brian Reichholf, Pablo Augusto Vieyra-Garcia, Yuka Nakamura, Shingo Sakashita, Masaki Nakamura, Hidehiro Hojo, Yuichiro Tsukada, Masaaki Ito, Kohei Shitara, , Shun‐Ichiro Kageyama
The paper identifies POSTN-expressing cancer-associated fibroblasts (CAFs) linked to chemoradiotherapy resistance in rectal cancer using spatial multi-omics data.
bioRxiv · May 5, 2026 · PreprintCancer Biology