Author

James A. Huntington

University of CambridgeORCID 0000-0003-0076-7204Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biochemistry· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Fatma Işık ÜstokiD· 2 shared Alan John WarreniD· 1 shared Alexandre FailleiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

Fatma Işık ÜstokORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Prothrombinase processivity is conferred by substrate allostery

Fatma Işık Üstok, Alexandre Faille, Alan John Warren, James A. Huntington

The paper presents cryo-EM structures of prothrombinase complexed with prothrombin and meizothrombin, revealing substrate allostery as the mechanism for processive cleavage.

The EMBO Journal · Apr 22, 2026Peer-reviewedBiochemistry

Engineering a membrane-independent human prothrombinase through parsimonious mutation of factor Xa

Fatma Işık Üstok, James A. Huntington

This study creates a PL-independent human prothrombinase by mutating factor Xa to mimic the high-affinity binding of HopD to fVa, achieving a Kd of ~20 nM.

Journal of Thrombosis and Haemostasis · Nov 5, 2025Peer-reviewedBiochemistry