Author

Alexandre Faille

Wellcome/MRC Cambridge Stem Cell InstituteORCID 0000-0002-0714-4133Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1

Frequent Co-Authors

Alan John WarreniD· 2 shared Akeel Abo AlardiD· 1 shared Alisa F. ZyryanovaiD· 1 shared Ana Crespillo-CasadoiD· 1 shared Christophe FromontiD· 1 shared David RoniD· 1 shared Fatma Işık ÜstokiD· 1 shared Felicity R. AlleniD· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

Alan John WarrenORCID

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2 papers

Recent·Most cited

BiochemistryThe EMBO JournalPeer-reviewedApr 22, 2026

Prothrombinase processivity is conferred by substrate allostery

Fatma Işık Üstok, Alexandre Faille, Alan John Warren, James A. Huntington

The paper presents cryo-EM structures of prothrombinase complexed with prothrombin and meizothrombin, revealing substrate allostery as the mechanism for processive cleavage.

DOI 10.1038/s44318-026-00782-4

experimental assay

Molecular BiologybioRxivPreprintNov 25, 2017

Binding of the integrated stress response inhibitor, ISRIB, reveals a regulatory site in the nucleotide exchange factor, eIF2B

Alisa F. Zyryanova, Félix Weis, Alexandre Faille…·David Ron

The paper identifies an ISRIB-binding site in eIF2B using cryo-EM and CRISPR/Cas9, showing its role in regulating translation through an allosteric mechanism.

1 citation

humanexperimental assay