Author

Fatma Işık Üstok

University of CambridgeORCID 0000-0001-7070-4175Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

James A. HuntingtoniD· 2 shared Alan John WarreniD· 1 shared Alexandre FailleiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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2 shared papersBiochemistry

James A. HuntingtonORCID

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2 papers

Recent·Most cited

BiochemistryThe EMBO JournalPeer-reviewedApr 22, 2026

Prothrombinase processivity is conferred by substrate allostery

Fatma Işık Üstok, Alexandre Faille, Alan John Warren, James A. Huntington

The paper presents cryo-EM structures of prothrombinase complexed with prothrombin and meizothrombin, revealing substrate allostery as the mechanism for processive cleavage.

DOI 10.1038/s44318-026-00782-4

experimental assay

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BiochemistryJournal of Thrombosis and HaemostasisPeer-reviewedNov 5, 2025

Engineering a membrane-independent human prothrombinase through parsimonious mutation of factor Xa

Fatma Işık Üstok, James A. Huntington

This study creates a PL-independent human prothrombinase by mutating factor Xa to mimic the high-affinity binding of HopD to fVa, achieving a Kd of ~20 nM.

3 citations

humanproteomics

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