Adrián Díaz

Scop3P-Toolkit provides an open-source framework for integrating PTMs, mutations, and proteomics data with structural and functional annotations to enable reproducible analysis.

Scop3P is updated to integrate phosphorylation sites with structural, functional, and mutational data, enhancing phosphosite interpretation and disease context.

Resource of 212 literature-curated chimeric class A GPCRs linked to 1,755 natural class A mammalian GPCRs, annotated at sequence, structure and biophysics level, with guidelines for designing new chimeras.

This study compares AlphaFold2's pLDDT metric with NMR and computational dynamics metrics, finding that AlphaFold2 poorly captures the gradations of protein dynamics observed by NMR.

D2Deep predicts cancer driver mutations by combining protein language models and evolutionary information, outperforming existing methods and enabling result interpretation.