Jennifer S.Y. Li

THRESHOLD evaluates gene saturation in disease progression using TCGA datasets, revealing co-regulation patterns and identifying biomarkers in bladder, prostate, and breast cancers.

VGC is a VCF file visualization and analysis tool that provides variant data extraction, visualization, and integration with external databases for gene function and variant interpretation.

The paper uses deep mutational scanning to explore how chemical perturbations affect ubiquitin's mutational tolerance, revealing sensitization of most positions except two.