BiophysicsbioRxivPreprint
G-Quadruplexes Act as an On/Off Switch While i-Motifs Regulate Insulin Expression in Reporter Gene Assays
Dilek Guneri, Christopher J. Morris, Yiliang Ding…·Zoë A. E. Waller
This study shows that both G-quadruplexes and i-motifs are required for glucose-induced transcriptional activation of the insulin gene, with i-motif stability positively correlating with promoter activity.
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