Dilek Guneri

This study investigates RNA i-motif stability at neutral pH, finding that while ensemble experiments show global unfolding, single-molecule experiments reveal a small fraction remains folded.

This paper introduces ATENA, a method using chemically modified CRISPR-Cas9 to target specific G-quadruplexes and i-motifs, showing ligand-dependent transcriptional changes in c-MYC.

The paper identifies peptide ligands that bind i-motif DNA structures and modulate c-Myc gene expression in HEK293 cells.

This study shows that both G-quadruplexes and i-motifs are required for glucose-induced transcriptional activation of the insulin gene, with i-motif stability positively correlating with promoter activity.

The paper introduces a machine learning tool, iM-Seeker, to predict DNA i-Motif folding status and strength using CUT&Tag data and biophysical experiments.

This study shows that DNA secondary structures like G4s and iMs cause replication fork arrest and breakage, and that Pif1 helicase is required to resolve stalled forks.