Napon Chirathivat

The paper identifies 132 master regulators of primed pluripotency in mouse epiblast stem cells and constructs a regulatory network revealing four functionally distinct modules.

This study shows that catalytically inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative manner, revealing its severe impact on normal tissues.

This study identifies Platr4 as an ESC-specific lncRNA that regulates meso/endoderm lineage commitment by interacting with Tead4 to control Ctgf expression, leading to cardiac defects in knockout mice.