Author

Zhengping Shao

Columbia UniversityORCID 0009-0001-0807-9353Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Brian J. LeeiD· 3 shared Shan ZhaiD· 3 shared Wenxia JiangiD· 2 shared Xiaohui LiniD· 2 shared Alan E. TomkinsoniD· 1 shared Angelina Li· 1 shared Chen Li· 1 shared Demis MenolfiiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersGenetics

Brian J. LeeORCID

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3 papers

Recent·Most cited

Catalytically inactive PARP1 protein drives PARP inhibitor induced hematological toxicity

Xiaohui Lin, Zhengping Shao, Denitsa Yaneva, Wenxia Jiang, Demis Menolfi, Seema Khattri Bhandari, Brian J. Lee, Mirjam Schmucker, Faye Yaneva, Alan E. Tomkinson, Julian Stingele, Shan Zha

This study shows that catalytically inactive PARP1, not PARP2, is responsible for PARP inhibitor-induced hematological toxicity in mice.

bioRxiv · Sep 25, 2026 · PreprintCancer Biology

Programmed Clonal Expansion Drives an ATM-Dependent Vulnerability Underlying Preferential Lymphocyte Depletion and Myeloid Bias Following DNA Damage

Katherine H Lee, Zhengping Shao, Yunyue Wang, Brian J. Lee, Angelina Li, Faye Yan, Peter A. Sims, Shan Zha

The paper identifies programmed clonal expansion during V(D)J recombination as an ATM-dependent vulnerability causing preferential lymphocyte depletion and myeloid bias after DNA damage.

bioRxiv · Aug 11, 2026 · PreprintGenetics

Inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative manner.

Zhengping Shao, Brian J. Lee, Hanwen Zhang, Xiaohui Lin, Chen Li, Wenxia Jiang, Napon Chirathivat, Steven Gershik, Michael M. Shen, Richard J. Baer, Shan Zha

This study shows that catalytically inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative manner, revealing its severe impact on normal tissues.

Proceedings of the National Academy of Sciences · Jul 24, 2023Peer-reviewedGenetics