Nick J. Patterson

The paper tracks genome-wide evolutionary dynamics in hybrid Drosophila populations, showing rapid purging of minority ancestry and repeated retention of selected regions through adaptive introgression.

This study presents genome-wide data from ancient individuals to trace the genetic legacy of the Balkan refugium during the Last Glacial Maximum and its impact on later European hunter-gatherer populations.

The paper uses ancient DNA to show matrilineal kinship structures and recurrent unions between dominant maternal groups in Iron Age Britain.

The paper shows that hunter-gatherer continuity persisted in the Rhine-Meuse region longer than in continental Europe, with Bell Beaker groups later disrupting this pattern through mixture.

The paper shows that Ancient DNA data from MZR is contaminated with modern Han Chinese ancestry, making it unreliable for population genetic analysis.

This paper uses ancient DNA data to trace the genetic origins of the Yamnaya culture and links their expansion to the spread of Indo-European languages.

This study analyzes genomic data from 78 prehistoric North Pontic individuals to trace genetic ancestry and migration patterns from the Neolithic to the Bronze Age.

This paper detects widespread directional selection in ancient DNA data, identifying 347 genome-wide significant loci and linking them to traits like body fat, skin color, and cognitive performance.

This study analyzes 2,762 whole genome sequences from diverse Indian populations to reconstruct 50,000 years of evolutionary history, revealing major admixture events and archaic hominin gene flow.

The paper describes the Allen Ancient DNA Resource (AADR), a curated compendium of ancient human genomes, and reports its growth to over 10,000 individuals with genome-wide data.

This paper introduces PSMC+, an extension of the PSMC algorithm that accounts for background selection in demographic inference, improving accuracy in effective population size estimation.

ancIBD identifies IBD segments in ancient DNA to detect relatives and migration patterns, revealing long-distance connections and Steppe ancestry spread in Europe.

The paper analyzes a bone fragment from a Trypillian site in Ukraine, showing dietary and genetic evidence of interaction between Trypillian farmers and North Pontic forager-pastoralists.

The paper tests three reagents for in-solution enrichment of ancient human DNA and introduces a subset of SNPs that can be co-analyzed with shotgun data.

This study analyzes ancient DNA from the Swahili coast to trace genetic admixture between African and Asian populations over time.

This paper introduces a non-parametric method to infer human genealogical history from modern and ancient genomes, demonstrating its ability to reconstruct relationships and identify descendants of ancient samples.

The paper analyzes genome-wide data from 66 ancient individuals from Kulubnarti to explore genetic ancestry and social stratification in Christian Period Nubia, finding no genetic differentiation between socially stratified cemeteries.

This paper shows that combining ancient DNA and radiocarbon dating can narrow date ranges for related individuals by incorporating biological constraints on death age separations.

This study evaluates qpAdm's performance in admixture analysis through simulations, finding it robust in many scenarios but cautioning against certain practices.

miqoGraph fits admixture graphs using mixed-integer quadratic optimization to infer topology, drift lengths, and admixture proportions simultaneously.

The paper develops ACLR to estimate genomic autocorrelation of causal SNP effects and finds significant negative autocorrelation at short distances in complex traits.

This paper introduces a new association method, LT-FH, that combines case-control status and family history to increase power in genetic association studies, outperforming existing methods across multiple diseases.

The paper reanalyzes UK Biobank data and finds no evidence for CCR5-Δ32 affecting lifespan, attributing previous findings to technical artifacts.

The paper uses ancient DNA data to trace the genetic origins and spread of Indo-European languages in South and Central Asia.

The paper analyzes ancient DNA from the Balearic Islands, Sicily, and Sardinia to trace the arrival and spread of Steppe and Iranian-related ancestries in the western Mediterranean, revealing complex admixture histories.

This paper analyzes ancient DNA from the Caucasus to show that a population around 26,000 years ago contributed significantly to modern West Eurasian ancestry.

The paper shows that polygenicity of complex traits is explained by negative selection, which flattens genetic signal across the genome.

The paper introduces a method to detect directional effects of transcription factor binding on disease risk using GWAS data and applies it to identify new causal genes and mechanisms.

The paper quantifies genetic components of population differentiation in UK Biobank traits to detect polygenic selection signals across geographic gradients.