Author

Wenfei Liu

University College LondonORCID 0000-0003-0322-4344Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Damian M. CummingsiD· 2 shared Dervis A. M. SalihiD· 2 shared Frances A. EdwardsiD· 2 shared John HardyiD· 2 shared Juan Antonio BotíaiD· 2 shared Rui WangiD· 2 shared Amy PetersoniD· 1 shared Andrew C Graham· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Damian M. CummingsORCID

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3 papers

Recent·Most cited

NeuroscienceHuman Molecular GeneticsPeer-reviewedSep 21, 2020

Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions

Wenfei Liu, Orjona Stella Taso, Rui Wang…·Dervis A. M. Salih

This study investigates how TREM2 influences microglial anti-inflammatory responses and shows that reduced TREM2 expression impairs anti-inflammatory gene expression and STAT6 levels.

214 citationstop 1%

mousebulk RNA-seq

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BioinformaticsScience AdvancesPeer-reviewedJun 10, 2020

Incomplete annotation of disease-associated genes is limiting our understanding of Mendelian and complex neurogenetic disorders

David Zhang, Sebastian Guelfi, Sonia García-Ruiz…·Mina Ryten

The paper identifies and validates novel transcription regions across tissues, improving gene annotation for 63% of OMIM-morbid genes and highlights tissue-specific and functionally significant variants.

66 citationstop 3%

humanwhole-exome sequencing

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NeuroscienceEBioMedicinePeer-reviewedDec 13, 2018

Effects of rising amyloidβ levels on hippocampal synaptic transmission, microglial response and cognition in APPSwe/PSEN1M146V transgenic mice

Evelyn Medawar, Tiffanie A. Benway, Wenfei Liu…·Frances A. Edwards

This study examines how rising amyloidβ levels affect synaptic transmission, microglial response, and cognition in APPSwe/PSEN1M146V transgenic mice before and after plaque formation.

26 citations

mouseexperimental assay

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