Frances A. Edwards

The paper identifies gene expression changes in microglia around Aβ plaques in human Alzheimer's disease tissue and finds cross-species concordance with mouse data.

This study investigates the effect of the Trem2 R47H variant on hippocampal synaptic transmission in young mice and finds no detectable changes in synaptic activity or density.

This paper introduces a new mouse model, NLFTaum/h, that shows ageing and amyloid-β can initiate tau pathology without MAPT mutations, revealing interactions between age, Aβ, and human tau.

This paper uses isotope-encoded mass spectrometry imaging and single plaque transcriptomics to track Aβ plaque maturation and its impact on synaptic function and toxicity in Alzheimer's disease.

This study investigates the effect of sodium channel inhibitors on plaque and tangle development in Alzheimer's mouse models, finding reduced tangle density with inhibitor treatment.

The paper shows that Trem2 gene expression in microglia is upregulated only when they contact plaques, and this effect is reduced by the Trem2R47H mutation.

The paper uses iSILK to track Aβ plaque aggregation dynamics in AD mouse models, identifying cortical deposition and structural heterogeneity in plaque composition.

This study investigates how TREM2 influences microglial anti-inflammatory responses and shows that reduced TREM2 expression impairs anti-inflammatory gene expression and STAT6 levels.

This study examines how rising amyloidβ levels affect synaptic transmission, microglial response, and cognition in APPSwe/PSEN1M146V transgenic mice before and after plaque formation.

The paper identifies 5 new Alzheimer's risk loci by comparing mouse amyloid microglial response with human GWAS gene-based SNPs.

This paper compares the effects of amyloid-beta plaques and Tau tangles in mouse models of dementia, showing that tangles cause severe neurodegeneration while plaques affect synaptic transmission and immunity earlier.