Xiguang Qi

This study shows that astrocytic D1 dopamine receptors in the nucleus accumbens shell regulate synaptic remodeling and cocaine seeking behavior in mice.

The paper examines how NAc neurons shift their activity patterns during cocaine self-administration training, finding expansion and refinement dynamics in neuronal ensembles.

The paper identifies three temporally sequenced clusters of NAc neuron activity in mice during reward seeking and shows that D1 and D2 neuron activity at specific times predicts and influences lever-pressing behavior.