Author

Kirk R. Henne

Denali Therapeutics (United States)ORCID 0000-0003-0370-2094Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:benchmarking· 1 Organism:human· 1 Assay:protein sequence· 1 Assay:protein structure· 1

Frequent Co-Authors

Hilda O. SolanoyiD· 3 shared Hoang Ngan NguyeniD· 3 shared Joseph W. LewcockiD· 3 shared Roni ChauiD· 3 shared Timothy EarriD· 3 shared Darren Chan· 2 shared Elysia Roche· 2 shared Isabel A. Becerra· 2 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Hilda O. SolanoyORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintNov 12, 2024

Transferrin receptor-mediated transport at the blood-brain barrier is elevated in early development but maintained across adult aging

Vanessa O. Torres, Michelle E. Pizzo, Darren Chan…·Y. Joy Yu Zuchero

This study investigates TfR-mediated BBB transport in mice across development and aging, finding elevated transport in early development and stability across adulthood, including in an AD model.

DOI 10.1101/2024.11.12.623253

mousehuman

𝕏 PostBluesky

NeuroscienceeLifePeer-reviewedNov 14, 2023

DNL343 is an investigational CNS penetrant eIF2B activator that prevents and reverses the effects of neurodegeneration caused by the Integrated Stress Response

Ernie Yulyaningsih, Jung H. Suh, Melania H. Fanok…·Pascal E. Sanchez

DNL343 reduces neurodegeneration in mouse models by inhibiting the integrated stress response and normalizing dysregulated biomarkers, with potential clinical relevance for vanishing white matter disease.

11 citations

mouseexperimental assay

𝕏 PostBluesky

NeuroscienceThe Journal of Experimental MedicinePeer-reviewedDec 17, 2021

Molecular architecture determines brain delivery of a transferrin-receptor targeted lysosomal enzyme

Annie Arguello, Cathal S. Mahon, Meredith Calvert…·Mihalis S. Kariolis

The paper compares brain delivery and efficacy of two TfR-targeted enzyme fusions in MPS II mice, finding the moderate-affinity ETV:IDS has better brain exposure and substrate reduction than the high-affinity IgG:IDS.

89 citationstop 4%

mouseprotein sequence

𝕏 PostBluesky