Author

Ernie Yulyaningsih

Denali Therapeutics (United States)ORCID 0000-0003-2110-2017Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Connie HaiD· 3 shared Thomas SandmanniD· 3 shared Anthony A. EstradaiD· 2 shared Hilda O. SolanoyiD· 2 shared Hoang Ngan NguyeniD· 2 shared Joseph W. LewcockiD· 2 shared Jung H. SuhiD· 2 shared Kimberly A. Scearce-LevieiD· 2 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Connie HaORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 6, 2025

CNS-penetrant NLRP3 inhibitor achieves durable weight loss and reverses hypothalamic inflammation in diet-induced obesity

Jing Guo, Tomás P. Bachor, Ryan Takahashi…·Ernie Yulyaningsih

TN-783, a CNS-penetrant NLRP3 inhibitor, induces sustained weight loss and reverses hypothalamic inflammation in diet-induced obese mice.

1 citation

mouseproteomics

𝕏 PostBluesky

NeuroscienceeLifePeer-reviewedNov 14, 2023

DNL343 is an investigational CNS penetrant eIF2B activator that prevents and reverses the effects of neurodegeneration caused by the Integrated Stress Response

Ernie Yulyaningsih, Jung H. Suh, Melania H. Fanok…·Pascal E. Sanchez

DNL343 reduces neurodegeneration in mouse models by inhibiting the integrated stress response and normalizing dysregulated biomarkers, with potential clinical relevance for vanishing white matter disease.

11 citations

mouseexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintJan 19, 2021

Fibrillar Aβ causes profound microglial metabolic perturbations in a novel APP knock-in mouse model

Dan Xia, Steve Lianoglou, Thomas Sandmann…·Pascal E. Sanchez

This paper characterizes microglial metabolic changes in an APP knock-in mouse model of AD, finding lipid dysregulation and immunometabolic perturbations linked to fibrillar Aβ.

5 citations

mouseexperimental assay

𝕏 PostBluesky

Ernie Yulyaningsih · henhao