Author

Dehua Lu

Shanghai UniversityORCID 0000-0003-0399-7769Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Bin XiiD· 1 shared Bo HuangiD· 1 shared Cheng ShiiD· 1 shared Haixian ZhangiD· 1 shared Han WangiD· 1 shared Qi Li· 1 shared Siyu XiuiD· 1 shared Wei FengiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBioinformatics

Bin XiORCID

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1 paper

Recent·Most cited

BioinformaticsbioRxivPreprintAug 27, 2026

A closed-loop reinforcement learning framework for rapid compound directed optimization

Han Wang, Dehua Lu, Weiping Lyu…·Zhenming Liu

This paper introduces RCDO, a closed-loop reinforcement learning framework that accelerates compound optimization by integrating experimental feedback with generative models, achieving significant improvements in drug candidate properties.

DOI 10.64898/2026.08.24.745890

machine learning (classical)drug response / drug discovery

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