Cheng Shi

This paper introduces RCDO, a closed-loop reinforcement learning framework that accelerates compound optimization by integrating experimental feedback with generative models, achieving significant improvements in drug candidate properties.

This study shows that piRNA pathway downregulation in the germline during mating releases Hedgehog signaling, leading to somatic aging and reduced lifespan.

The paper investigates how male sexual interactions negatively affect female and hermaphrodite lifespan in C. elegans, uncovering genes involved in male-induced demise and longevity pathways.

This study shows that oleic acid rescues mating-induced death in C. elegans by restoring fat storage, suggesting a role for fat metabolism in uncoupling reproduction from lifespan.

This study investigates how mating affects male lifespan in Caenorhabditis species, identifying two mechanisms: germline-dependent lifespan reduction and pheromone-mediated toxicity.