Amy M. Smith

The paper uses single-cell Mendelian randomisation to identify cell-type specific genetic effects on brain disease and behaviour, revealing 118 genes with causal associations to 16 brain phenotypes.

The paper identifies transcriptional signatures in vascular cells from Alzheimer's disease brains, revealing dysregulated pathways linked to vascular dysfunction and immune activation.

This study identifies cell type-specific immune alterations in bipolar disorder brains, showing reduced proinflammatory microglia and metabolic/immune dysregulation in astrocytes.

The paper shows TSPO expression increases in activated microglia in rodent models but not in human neurodegenerative diseases, indicating species-specific differences in TSPO function.

This study uses single-nuclei RNA sequencing to analyze astrocyte and microglial transcriptomes in Alzheimer's disease brains, identifying gene expression differences linked to amyloid-beta and phospho-tau pathology.

This study uses transcriptomic profiling to identify common and distinct molecular features across Lewy Body diseases, highlighting RNA splicing dysregulation and potential therapeutic targets.