Molecular BiologyBiomedicinesPeer-reviewed
Defective proinsulin handling modulates the MHC I bound peptidome and activates the inflammasome in β-cells
Muhammad Saad Khilji, Pouya Faridi, Erika Pinheiro-Machado…·Michał Marzec
This study shows that impaired proinsulin handling in β-cells increases MHC-I bound peptides and activates inflammasomes, potentially contributing to autoimmune diabetes.
7 citations