Michał Marzec

This study identifies FKBP2 as a regulator of proinsulin folding and β-cell differentiation through NFAT and HDAC9, revealing its role in ER stress and diabetes pathogenesis.

This study identifies FKBP2 as a proline isomerase involved in proinsulin folding, showing its role in preventing misfolding and apoptosis in β-cells.

This study shows that impaired proinsulin handling in β-cells increases MHC-I bound peptides and activates inflammasomes, potentially contributing to autoimmune diabetes.

The paper shows that inducible proteasomal subunits are constitutively expressed in pancreatic beta cells and upregulated by IL-1β, enhancing proteasome activity and potentially influencing autoantigen presentation.