Anthony Wayne Purcell

Unconventional presentation of an immunodominant HLA-DR15-restricted nephritogenic proteinase 3 epitope implicated in vasculitis

The paper identifies a novel HLA-DR15-restricted CD4 T cell epitope from PR3 associated with vasculitis and describes its unconventional presentation mechanism.

Identification of HLA-A33-restricted CD8+ T cell epitopes from avian influenza A/H5N1

Immunopeptidomics shows HLA-A*33:01 and HLA-A*33:03 present largely distinct influenza peptide repertoires, and four HLA-A*33:03-restricted epitopes triggered CD8+ T cell responses in A/H5N1-naive donors.

Generative design of antigen-specific T-cell receptor sequences with a conditional diffusion model

This paper introduces TCRDiff, a conditional diffusion model for generating antigen-specific TCR sequences, validated through in vitro assays.

Temporal expression of liver-stage malaria antigens shapes vaccine efficacy

The paper identifies temporal expression patterns of liver-stage malaria antigens and shows that combining antigens with different temporal profiles improves vaccine efficacy.

A quantitative approach to poxvirus infection reveals general correlates of antigen presentation and immunogenicity for viral CD8+ T cell epitopes

This study quantifies antigen presentation kinetics and immunogenicity of viral epitopes during poxvirus infection, revealing that epitope levels correlate with immunogenicity only when measured ex vivo.

The antigen presenting molecule MR1 binds riboflavin catabolites

This study identifies riboflavin catabolites that bind MR1, reduce its cell surface expression, and inhibit MAIT cell activation.

A transgenic mouse allows to capture the HLA-C*06:02 immunopeptidome in a model of psoriasis

The paper presents a comprehensive HLA-C*06:02 immunopeptidome dataset from psoriasis-relevant cell lines and psoriasiform skin using a transgenic mouse model.

Epitope-anchored contrastive transfer learning for paired CD8+ T cell receptor-antigen recognition

This paper introduces EPACT, a deep-learning framework for predicting TCR-antigen binding pairs, showing high accuracy in epitope recognition and TCR repertoire analysis.

TCR_Explore: a novel webtool for T cell receptor repertoire analysis

TCR_Explore is a webtool for TCR repertoire analysis that automates quality control and analysis, enabling non-expert users to generate publication-ready figures.

Defective proinsulin handling modulates the MHC I bound peptidome and activates the inflammasome in β-cells

This study shows that impaired proinsulin handling in β-cells increases MHC-I bound peptides and activates inflammasomes, potentially contributing to autoimmune diabetes.

Towards a systematic characterization of protein complex function: a natural language processing and machine-learning framework

PCfun annotates protein complex function using natural language processing and machine learning, integrating word embeddings from PubMed Central articles with supervised and unsupervised methods.

Immunopeptidomics for Dummies: Detailed Experimental Protocols and Rapid, User-Friendly Visualization of MHC I and II Ligand Datasets with MhcVizPipe

The paper provides detailed experimental protocols and an open-source tool, MhcVizPipe, for analyzing MHC I and II ligand datasets in immunopeptidomics.

Systematic protein complex profiling and differential analysis from co-fractionation mass spectrometry data

The paper introduces PCprophet, a computational framework for identifying and analyzing protein complexes from co-fractionation mass spectrometry data across conditions.

Mouse and human microglial phenotypes in Alzheimer’s disease are controlled by amyloid plaque phagocytosis through Hif1α

This study identifies that amyloid plaque phagocytosis through Hif1α controls microglial phenotypes in Alzheimer’s disease in both mice and humans.