Author

Justyna E. Klusek

Jan Kochanowski UniversityORCID 0000-0002-1098-8919Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

Carolin HoefneriD· 2 shared Michał MarzeciD· 2 shared Muhammad Saad KhiljiiD· 2 shared Thomas R Mandrup-PoulseniD· 2 shared Anthony Wayne PurcelliD· 1 shared Celina PihliD· 1 shared Edyta Urbaniak· 1 shared Erika Pinheiro-MachadoiD· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMolecular Biology

Carolin HoefnerORCID

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Author profile →

2 papers

Recent·Most cited

FK506-binding protein 2 participates in proinsulin folding

Carolin Hoefner, Tenna Holgersen Bryde, Celina Pihl, Sylvia Naiga Tiedemann, Sophie Emilie Bresson, Hajira Ahmed Hotiana, Muhammad Saad Khilji, Theodore dos Santos, Michele Puglia, Paola Pisano, Mariola Majewska, Julia Durzyńska, Kristian Klindt, Justyna E. Klusek, Marcelo Javier Perone, , Michał Marzec

This study identifies FKBP2 as a proline isomerase involved in proinsulin folding, showing its role in preventing misfolding and apoptosis in β-cells.

Biomolecules · Jan 11, 2023Peer-reviewedMolecular Biology

Defective proinsulin handling modulates the MHC I bound peptidome and activates the inflammasome in β-cells

Muhammad Saad Khilji, Pouya Faridi, Erika Pinheiro-Machado, Carolin Hoefner, Tina Dahlby, Ritchlynn Aranha, Søren Buus, Morten Nielsen, Justyna E. Klusek, Thomas R Mandrup-Poulsen, Kirti Pandey, Anthony Wayne Purcell, Michał Marzec

This study shows that impaired proinsulin handling in β-cells increases MHC-I bound peptides and activates inflammasomes, potentially contributing to autoimmune diabetes.

Biomedicines · Mar 30, 2022Peer-reviewedMolecular Biology