Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis
Kartik Bhamidipati, Alexa B. R. McIntyre, Shideh Kazerounian…·Kevin Wei
Perivascular COMPhi fibrogenic fibroblasts expand in treatment-refractory rheumatoid arthritis synovium, where endothelial Notch signaling patterns fibroblast TGF-beta sensitivity via TGFBR3 regulation and persists despite post-treatment immune cell depletion.