Cheryl L. Ackert‐Bicknell

This study investigates genetic and sex-specific factors influencing bone response to PTH in mice, finding strong heritability and sex-dependent mechanisms.

The paper investigates the role of microbial influenced corrosion (MIC) in causing spine rod fractures by analyzing tissue samples from patients with titanium implants.

Perivascular COMPhi fibrogenic fibroblasts expand in treatment-refractory rheumatoid arthritis synovium, where endothelial Notch signaling patterns fibroblast TGF-beta sensitivity via TGFBR3 regulation and persists despite post-treatment immune cell depletion.

This study identifies 14 genome-wide significant loci for obstructive sleep apnea, including three independent of BMI, and highlights genetic pathways involving obesity, neurological, and craniofacial factors.

The paper integrates GWAS data with a CRISPRi screen in osteoblasts to identify genes affecting bone mineral density and reveals pleiotropy across non-bone tissues.

The paper identifies 512 potentially causal genes for bone mineral density using TWAS and eQTL colocalization, with PPP6R3 validated in mice.

The paper introduces SEESAW, a method to detect isoform-level allelic imbalance while accounting for inferential uncertainty, and evaluates it on simulated and real RNA-seq data.

The paper uses whole-genome RNA sequencing to compare cartilage transcriptomes of FAI and OA patients, identifying FGF18 as a potential biomarker for hip OA progression.

This study identifies 59 genome-wide significant loci for skull bone mineral density, including four novel loci, and links them to osteoporosis and craniofacial developmental defects.

This study identifies 15 genetic loci associated with muscle weakness in older adults through a large meta-analysis, revealing new pathways linked to aging and health outcomes.

The paper identifies a core gene module for bone mineral density by integrating co-expression networks and GWAS data, revealing four novel causal genes.

The paper identifies Zbtb40 as a regulator of osteoblast activity and bone mass through genetic analysis in mice, showing reduced BMD and mineralization upon Zbtb40 knockdown.

The paper uses high-resolution imaging and QTL analysis to study genetic control of bone microarchitecture in mice, identifying 50 candidate genes with potential roles in bone biology.

This study identifies Lhfp as a regulator of bone mass through GWAS and systems genetics in mice, showing its role in osteoblast differentiation and increased BMD.

This paper identifies 518 genetic loci associated with bone mineral density and fracture risk, validates causal genes in mice, and provides insights for osteoporosis drug development.