Alexa B. R. McIntyre

The paper identifies fibroblast-derived neurotrophin signaling as a driver of abnormal vascular maturation in RA synovia and shows that neurotrophin inhibitors can reverse this process.

Perivascular COMPhi fibrogenic fibroblasts expand in treatment-refractory rheumatoid arthritis synovium, where endothelial Notch signaling patterns fibroblast TGF-beta sensitivity via TGFBR3 regulation and persists despite post-treatment immune cell depletion.

The paper uses direct RNA long-read sequencing to show m6A modifications on adenovirus RNA are necessary for efficient splicing.

This study evaluates the reproducibility of m6A peak detection and changes using MeRIP-seq and finds limited consistency across studies.

This study shows that Flaviviridae viruses alter m6A modification of specific host transcripts, affecting viral infection through changes in translation and splicing.

This study improves the detection of m6A in bacterial DNA using nanopore sequencing with a binary classifier, highlighting the importance of read quality and comparing results to PacBio methylation calls.

This study benchmarks eleven metagenomic classifiers using 846 species and evaluates strategies to reduce false positives in taxonomic classification.

This study evaluates nanopore sequencing performance on the ISS, showing no performance decrease and successful genome assembly of bacterial and mammalian samples.