Author

Leah A. Santat

California Institute of TechnologyORCID 0000-0003-0511-9740Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 1

Frequent Co-Authors

Michael B. ElowitziD· 2 shared Nagarajan NandagopaliD· 1 shared Rachael KuintzleiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

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3 top collaborators · 2 mutual co-author links

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2 shared papersSystems Biology

Michael B. ElowitzORCID

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2 papers

Recent·Most cited

Systems BiologyeLifePeer-reviewedJan 3, 2025

Diversity in Notch ligand-receptor signaling interactions

Rachael Kuintzle, Leah A. Santat, Michael B. Elowitz

The paper systematically characterizes Notch ligand-receptor signaling interactions, showing unique profiles of trans-activation, cis-inhibition, and cis-activation across different ligands and receptors.

9 citations

mouseexperimental assay

𝕏 PostBluesky

BioinformaticseLifePeer-reviewedJan 10, 2019

Cis-activation in the Notch signaling pathway

Nagarajan Nandagopal, Leah A. Santat, Michael B. Elowitz

The paper shows cis-ligands can activate Notch receptors, similar to trans-activation, and demonstrates its role in neural stem cell survival and differentiation.

104 citationstop 3%

experimental assay

𝕏 PostBluesky