Alexander Stein

This study uses single-cell and spatial multi-omics to analyze a malignant peripheral nerve sheath tumor, revealing chromosomal instability drives phenotypic diversity and spatial-temporal evolution.

The paper calculates selective sweep probabilities in spatially expanding populations and finds they depend on mutant and wildtype expansion speeds and spatial dimension, with implications for tumour evolution.

This study uses stochastic models to analyze how genetic intra-tumour heterogeneity changes during and after treatment, finding distinct patterns in mutation frequencies and resistant clone sizes.